Prediction of lithium response by 31P-MRS in bipolar disorder
نویسندگان
چکیده
منابع مشابه
Lithium treatment for bipolar disorder.
This section looks back to some of the ground-breaking contributions to public health, reproducing them in their original form and adding a commentary on their significance from a modern-day perspective. To complement this month’s theme of the Bulletin, Philip B. Mitchell and Dusan Hadzi-Pavlovic review the 1949 paper by John F.J. Cade on the use of lithium salts in the treatment of psychotic e...
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INTRODUCTION: Abnormal glutamate (Glu) neurotransmission has been suspected to underlie neuronal dysfunction in bipolar disorder (BD). When studying Glu with short TE PRESS (Point RESolved Spectroscopy) spectra, the overlapping resonance signals presented as Glx around 2.35 ppm of chemical shift arise from Glu, glutamine (Gln), and γ-amino butyric acid, complicating the quantification of Glu. I...
متن کاملValidating MARK2 Gene Polymorphism as a Predictor of Response to Lithium Treatment in Bipolar Patients
Background: Lithium is a therapeutic option for the treatment of the acute phase of the bipolar disorder and long-term management of this disorder. However, it is estimated that 10 to 60% of patients do not properly response to this medication. Methods: To investigate the role of MARK2 gene in response to lithium, we genotyped the MARK2 rs10792421 polymorphism in Iranian bipolar pa...
متن کامل[Magnetic resonance spectroscopy (MRS) applications in bipolar disorder].
OBJECTIVE Magnetic resonance spectroscopy (MRS) is a noninvasive in vivo imaging technique that can directly assess the living biochemistry in localized brain regions without involving ionizing radiation. This review provides a brief description of spectroscopy, followed by a literature review of the key spectroscopy findings in bipolar disorder. METHOD We conducted a Medline literature revie...
متن کاملA safe lithium mimetic for bipolar disorder
Lithium is the most effective mood stabilizer for the treatment of bipolar disorder, but it is toxic at only twice the therapeutic dosage and has many undesirable side effects. It is likely that a small molecule could be found with lithium-like efficacy but without toxicity through target-based drug discovery; however, therapeutic target of lithium remains equivocal. Inositol monophosphatase is...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2000
ISSN: 1461-1457
DOI: 10.1017/s1461145799001674